Transdermal and Transmucosal Powdered Drug Delivery

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Abstract
High-velocity powder injection is a promising new drag-delivery technique that provides needle- and pain-free delivery of traditional drags, drags from biotechnology such as proteins, peptides, and oligonucleotides as well as traditional and genetic vaccines. The energy of a transient helium gas jet accelerates fine drag particles of 20 μm-100 μm diameter to high velocities and delivers them into skin or mucosal sites. This review describes the configuration and operating principles of devices that accelerate the particles, the required properties of the particles, the characteristics of the target tissues, and features of the developmental test methods. Preclinical and clinical results that best characterize the technology and introduce its potential as a drug-delivery platform are presented.

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