Causal Relationship between Neuropathy and Prolonged Linezolid Use

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Abstract
Sir—We read with great interest the article by Lee et al. [1] about 2 cases of linezolid-associated toxic neuropathy. We recently reported a very similar case [2], which occurred in a patient who had been receiving linezolid therapy for ∼11 months for a prosthetic knee infection due to methicillin-resistant Staphylococcus epidermidis that persisted despite administration of several prolonged courses of treatment with intravenous and/or oral antibiotics and multiple surgical revisions. In our case, significant ocular hypertension was initially present, and transient high-dose corticotherapy was started, allowing prompt normalization of the ocular hypertension and progressive amelioration of the bilateral optic neuritis. We would like to known whether ocular hypertension was also present in the 2 patients described by Lee et al. [1] as well as whether corticotherapy was considered.