Comprehensive behavioral phenotyping of calpastatin-knockout mice
Open Access
- 1 January 2008
- journal article
- research article
- Published by Springer Nature in Molecular Brain
- Vol. 1 (1) , 1-15
- https://doi.org/10.1186/1756-6606-1-7
Abstract
Calpastatin is an endogenous inhibitor of calpain, intracellular calcium-activated protease. It has been suggested to be involved in molecular mechanisms of long-term plasticity and excitotoxic pathways. However, functions of calpastatin in vivo are still largely unknown. To examine the physiological roles of calpastatin, we subjected calpastatin-knockout mice to a comprehensive behavioral test battery. Calpastatin-knockout mice showed decreased locomotor activity under stressful environments, and decreased acoustic startle response, but we observed no significant change in hippocampus-dependent memory function. These results suggest that calpastatin is likely to be more closely associated with affective rather than cognitive aspects of brain function.Keywords
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