DIURNAL CHANGES IN THE FUNCTION OF THE PANCREATIC ISLETS OF RATS AS INDICATED BY NUCLEAR SIZE IN THE ISLET CELLS

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Abstract
Existence of diurnal variation in the nuclear size of the islet cells was shown in 60 male rats. The size of the nuclei of the B cells shows a biphasic curve with one maximum at 12.00 A.M. and one at 12:00 P.M. The midday peak, in contrast to that at midnight, is probably significantly different from the nearest points on either side, but the midnight peak is found at the top of a successively rising curve. The A cells in general have a monophasic curve with high values during the later daylight hours, and there is a significant reduction of values between 8:00 P.M. and 12 P.M. The curve which illustrates the relationship between the nuclear size of the B and A cells was probably biphasic with a marked minimum at 8:00 P.M. and a clear maximum at 12:00 P.M. This difference is significant.

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