Recognition by Human V γ 9/V δ 2 T Cells of a GroEL Homolog on Daudi Burkitt's Lymphoma Cells
- 30 November 1990
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 250 (4985) , 1269-1273
- https://doi.org/10.1126/science.1978758
Abstract
All human γδ T cells coexpressing the products of the variable (V) region T cell receptor (TCR) gene segments V γ 9 and V δ 2 recognize antigens from some mycobacterial extracts and Daudi cells. Exogenous and endogenous ligands on the cell surface, homologous to the groEL heat shock family, induced reactivities that resembled superantigen responses in this major subset of human peripheral blood γδ T cells. Stimulation of human V γ 9/V δ 2 T cells is not restricted by human leukocyte antigens (HLA), including nonpolymorphic β 2 -microglobulin (β 2 M)-associated class Ib molecules. These data may be important for understanding the role of γδ T cells in autoimmunity and in responses to microorganisms and tumors.Keywords
This publication has 80 references indexed in Scilit:
- Recognition of heat shock proteins and γΔ cell functionImmunology Today, 1990
- Heat shock proteins and the immune responseImmunology Today, 1990
- Recognition of cluster of differentiation 1 antigens by human CD4−CD8>− cytolytic T lymphocyteNature, 1989
- Monoclonal antibodies which react with the T cell receptor γ/δ recognize different subsets of CD3WT31‐ T lymphocytesEuropean Journal of Immunology, 1989
- Specificity and function of T cells bearing γδ receptorsImmunology Today, 1988
- T-cell antigen receptor genes and T-cell recognitionNature, 1988
- Extensive Junctional Diversity of Rearranged Human T Cell Receptor δ GenesScience, 1988
- The 65kDa antigen of mycobacteria—a common bacterial protein?Immunology Today, 1987
- Human T-cell γ genes contain N segments and have marked junctional variabilityNature, 1986
- Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigensHuman Immunology, 1984