THE CONDITIONED URINARY PROTEIN EXCRETION TEST IN THE STUDY OF CHRONIC AND OBSCURE PROTEINURIA

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Abstract
INTRODUCTION TO EXHIBIT THIS REPORT covers a study of over four years' duration of approximately 4500 young males, referred to U. S. Army Hospital, Fort Jay, N. Y., because of proteinuria. Experiences with the urinary protein excretion test have been previously reported.1,4,5 The evaluation of renal disease through observed alterations in urinary protein excretion with postural change and activity is not a new concept. 6,7 The necessity for accurate urine collections, to assure that specimens correctly represent specific periods, has not been emphasized. Pooling of specimens and dilution are common sources of error. Although most patients will follow suitable instructions, there is a stubborn minority requiring close supervision. Clearly defined standards of interpretation, with rejection of noninterpretable tests, repeated as required, yield reliable results that can be duplicated in approximately 95% of cases. Considerable collateral information has been developed in this study. Prevalent concepts concerning orthostatic proteinuria require revision.

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