THE EFFECT OF POLYMORPHONUCLEAR LEUKOCYTES ON BLAST TRANSFORMATION OF LYMPHOCYTES IN HUMAN MIXED LEUKOCYTE CULTURES

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Abstract
Mixed leukocyte cultures which have been artificially depleted of their polymorphonuclear leukocytes have been shown to have impaired blast transformation. The results of human MLR cultures which contain polymorphs within the normal range have been analyzed statistically to determine whether variation in polymorph numbers within the normal physiological limits affects the degree of lymphocyte transformation. It is found that polymorph numbers may affect the degree of lymphocyte-macrophage transformation. The number of polymorphs present in cultures does not appear to exert any significant effect on the degree of lymphocyte-to-blast transformation.

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