Differential patterning of behavioral effects from three types of stimulant drugs

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Abstract
The effects of the new drug 5‐phenyl‐2‐imino‐4‐oxo‐oxazolidine (PIO) in young normal subjects were compared with amphetamine and caffeine 3 and 6 hours after oral administration. The test battery included a difficult code‐tracking task performed under forced speed conditions, a needle‐threading test for assessment of fine motor coordination, flicker fusion, and the Archimedes spiral. Pulse rate was recorded as a check for undesirable circulatory effects.The results point to the conclusion that PIO has a much more potent facilitating effect on code‐tracking performance under speed stress than amphetamine or caffeine. A slight improvement in fine motor coordination after 3 hours was observed only under amphetamine. Caffeine but not PIO caused a decrement in the same test parameter after both 3 and 6 hours. Increased duration of visual movement aftereffect was observed 3 hours after amphetamine, caffeine, and PIO, this effect being most persistent after amphetamine. The average increase in pulse rate over 6 hours after amphetamine was 4.6 beats per minute, after caffeine 1.8, and after PIO 0.7.

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