Effects of Ascorbic Acid on Collagen Synthesis in Nonmitotic Human Diploid Fibroblasts

Abstract
Human diploid fibroblasts maintained in a nonmitotic state by reducing the serum concentration of the incubation medium to 0.5% were shown to be metabolically functional with respect to collagen synthesis. Collagen synthesis was maintained for an extended time and responded to elevated ascorbic acid levels in a manner similar to that reported for other human diploid cell populations.

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