Independent differentiative pathways of Ly1 and Ly23 subclasses of T cells. Experimental production of mice deprived of selected T-cell subclasses.

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Abstract
When B mice are supplied with Ly1 or Ly23 cells they acquire, over the next 6 mo., only the immune functions associated with each of these T[thymus-derived]-cell subclasses, respectively. The T-cell population of these B-Ly1 and B-Ly23 mice also remains restricted to the Ly1 and Ly23 subclass phenotypes. Thus the Ly1 and Ly23 populations are derived from 2 separate lines of differentiation and are not sequential stages of a single differentiative pathway.