In vitro activity and serum protein-binding of cefaclor

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Abstract
The in vitro susceptibility of anaerobic and aerobic bacteria to cefaclor, cephalexin, and penicillin G were compared. Cefaclor was two- to fourfold more inhibitory than cephalexin against susceptible Gram-negative bacilli and Staphylococcus aureus. Both drugs were active against streptococci and anaerobes other than B. fragilis but were distinctly less potent than penicillin G. Ultrafiltration serum protein-binding studies revealed that cefaclor was approximately 50% bound while the corresponding value for cephalexin was only 17 to 20%. The results indicate that cefaclor is moderately more active than cephalexin against S. aureus and susceptible Gram-negative bacilli, but suggest that oral cephalosporins should be used with caution in anaerobic infections.

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