BRONCHIAL AND INTRAVENOUS PROVOCATION TESTS WITH INDOMETHACIN IN ASPIRIN-SENSITIVE ASTHMATICS

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Abstract
To elucidate the mechanisms involved in analgesic-induced asthma, bronchial and i.v. challenge tests with indomethacin were performed in 5 aspirin-sensitive asthmatics. Bronchial challenge with less than 2 mg of indomethacin elicited bronchoconstriction that developed immediately in most cases, reached its maximum at a mean time of 64 min, and was over within 2-4 h. The time sequence of the reaction after i.v. challenge was similar to that after bronchial challenge, except that to obtain a comparable degree of bronchoconstriction it was necessary to administer at least 2 .times. the inhaled dose. Inhalation of disodium cromoglycate during bronchoconstriction inhibited the reaction within 8.6 .+-. 5.7, min, regardless of the route of challenge. Apparently sequential mast cell degranulation with liberation of chemical mediators is the mechanism responsible for bronchoconstriction in analgesic-induced asthma.