Two-dimensional exchange difference spectroscopy Applications to indirect observation of quadrupolar relaxation

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Abstract
A novel type of difference spectroscopy is proposed to improve two-dimensional exchange spectroscopy by reducing diagonal peaks which are often dominant in complex cases such as in 2-D NOE spectra of biopolymers. The diagonal peaks appear with negative algebraic sign and amplitudes equal to the sums of all cross-peaks appearing in a column or row of the 2-D exchange spectra, in agreement with the elements of the corresponding exchange matrices. For demonstration purposes, the technique is applied to the indirect observation of quadrupolar relaxation of deuterium.