APOE-ε4 predicts incident AD in Japanese-American men: The Honolulu–Asia Aging Study
- 11 April 2000
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 54 (7) , 1526-1529
- https://doi.org/10.1212/wnl.54.7.1526
Abstract
Article abstract The authors assessed the 3-year incidence of dementia, including subtypes, in 2,603 Japanese-American men 71 to 93 years of age who were dementia free at baseline. There were 137 new cases of dementia according to the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised, including 51 with a primary diagnosis of AD. The rates for all subtypes increased with age. Men with an APOE4 allele had a significantly increased risk of AD of 2.39 (95% CI, 1.07, 5.31), after adjusting for age and education. There was no significant relationship of APOE4 with other subtypes of dementia.Keywords
This publication has 10 references indexed in Scilit:
- Estimating incidence of dementia subtypes: assessing the impact of missed casesStatistics in Medicine, 2000
- The incidence of dementiaNeurology, 1998
- Apolipoprotein E Polymorphism in Patients with Alzheimer’s Disease, Vascular Dementia and Ischemic Cerebrovascular DiseaseDementia and Geriatric Cognitive Disorders, 1998
- The APOE-∊4 Allele and the Risk of Alzheimer Disease Among African Americans, Whites, and HispanicsJAMA, 1998
- Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer DiseaseJAMA, 1997
- Apolipoprotein E ϵ4 and Incidence of Alzheimer Disease in a Community Population of Older PersonsPublished by American Medical Association (AMA) ,1997
- Prevalence of Dementia in Older Japanese-American Men in HawaiiJAMA, 1996
- Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's diseaseThe Lancet, 1996
- Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese populationNeurology, 1995
- The Cognitive Abilities Screening Instrument (CASI): A Practical Test for Cross-Cultural Epidemiological Studies of DementiaInternational Psychogeriatrics, 1994