Importance of P‐glycoprotein for drug disposition in humans
- 20 October 2003
- journal article
- review article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 33 (s2) , 6-9
- https://doi.org/10.1046/j.1365-2362.33.s2.4.x
Abstract
The ATP‐binding cassette transporter P‐glycoprotein is now recognized as an important determinant for disposition of multiple drugs. The use of P‐glycoprotein‐expressing cell lines, the generation of...Keywords
This publication has 37 references indexed in Scilit:
- Multidrug resistance in cancer: role of ATP–dependent transportersNature Reviews Cancer, 2002
- Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestineEuropean Journal of Pharmaceutical Sciences, 2000
- Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in miceReproductive Toxicology, 1998
- The barrier function of CYP3A4 and P-glycoprotein in the small bowelAdvanced Drug Delivery Reviews, 1997
- Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapyMolecular Carcinogenesis, 1995
- BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTERAnnual Review of Biochemistry, 1993
- Is the multidrug transporter a flippase?Trends in Biochemical Sciences, 1992
- Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.Journal of Histochemistry & Cytochemistry, 1990
- Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.Proceedings of the National Academy of Sciences, 1989
- Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.Proceedings of the National Academy of Sciences, 1987