Effect of α‐ and β‐receptor active drugs on corneal thickness

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Abstract
Phenylephrine (10 mg/ml), phentolamine (10 mg/ml), isoprenaline (0.5 mg/ml) and timolol (5 mg/ml) were applied topically to 1 eye of volunteers with normal corneas, the other eye serving as a control. One drop of each drug was given twice a day for 3 or 4 days. Timolol was found to increase corneal thickness in both the medicated and the control eye. A significantly greater effect was noted on the eye receiving the drug directly. When isoprenaline was given for 3 days, a slight significant decrease in corneal thickness was detected in both the medicated and the control eye, with the 2 eyes exhibiting a similar CCT [conceptial clustering test] change. The present results are suggestive of endothelial .beta.-receptor importance in the regulation of corneal thickness.