The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells
Open Access
- 1 April 1998
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Leukocyte Biology
- Vol. 63 (4) , 418-428
- https://doi.org/10.1002/jlb.63.4.418
Abstract
This review focuses on the emerging body of literature suggesting a critical role for CD40/CD154 interactions in antigen‐presenting cell (APC) activation, CD4+ and CD8+ T cell priming, and effector T cell maturation. In this context effective antigen presentation involves not only T cell expansion and long‐term survival but also the ability of the APC to guide the T cell response toward the Th1 (interferon‐γ producing) or the Th2 (interleukin‐4 producing) phenotype. We suggest a model to explain why CD40/CD154 interactions are critical for some helper and cytotoxic T cell responses, whereas others occur independently of this receptor/ligand pair. In addition, we will discuss the potential role for CD40/CD154 interactions in effector T cell maturation and cytokine production. J. Leukoc. Biol. 63: 418–428; 1998.Keywords
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