Prospects in Asthma Therapy: Disodium Cromoglycate and Diethylcarbamazine

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Abstract
Asthma is a syndrome of varying etiology in which the principal pathologic features include bronchospasm, mucosal edema and hypersecretion of mucus resulting in ventilatory insufficiency manifested clinically as wheezing, dyspnea, cough and mucoid expectoration.1 The pathogenesis of extrinsic asthma may involve the immunologic release of various chemical mediators of inflammation, including histamine and slow reacting substance of anaphylaxis (SRS-A). The finding that the lungs of allergic human beings challenged in vitro with specific pollen antigen results in the release of histamine and SRS-Ahu2 does not exclude the possible role of other mediators not yet studied. Passive sensitization of normal human . . .