ACROMEGALY DUE TO PRODUCTION OF A GROWTH HORMONE RELEASING FACTOR BY A BRONCHIAL CARCINOID TUMOUR
- 1 January 1979
- journal article
- research article
- Published by Wiley in Clinical Endocrinology
- Vol. 10 (1) , 61-67
- https://doi.org/10.1111/j.1365-2265.1979.tb03034.x
Abstract
We have studied growth hormone production in a patient with a bronchial carcinoid and acromegaly. The absence of growth hormone from the carcinoid tumour was demonstrated by extraction, cell culture and immunoperoxidase techniques. Using a linked perfusion culture system, effluent from the bronchial carcinoid tumour culture stimulated a rapid release of growth hormone from a rat pituitary mono‐layer. This is the first time evidence of growth hormone releasing activity by a bronchial carcinoid has been demonstrated in a patient with the clinical and biochemical manifestations of excess growth hormone production.This publication has 23 references indexed in Scilit:
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