Increased Intraepithelial Innervation in Women with Vulvar Vestibulitis Syndrome
- 1 November 1998
- journal article
- research article
- Published by S. Karger AG in Gynecologic and Obstetric Investigation
- Vol. 46 (4) , 256-260
- https://doi.org/10.1159/000010045
Abstract
Women with vulvar vestibulitis syndrome (VVS) suffer from severe pain and discomfort in the area around the introitus at almost any stimulus that causes pressure within the vestibule. In spite of the severe sensory symptoms present in these women, the influence of the peripheral nerves in the vulvar vestibulum has not been clarified before. In this study the nerve supply in the vestibular mucosa in women with VVS and in healthy women free from vulvar symptoms has been revealed by PGP 9.5 immunohistochemistry. The results show a significant increase in the number of intraepithelial nerve endings in women with VVS, indicating an alteration in the nerve supply in the afflicted area.Keywords
This publication has 1 reference indexed in Scilit:
- Vulvar Pain SyndromeObstetrical & Gynecological Survey, 1995