Antibodies to melanocytes. Occurrence in patients with vitiligo and chronic mucocutaneous candidiasis
- 1 November 1981
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 117 (11) , 705-708
- https://doi.org/10.1001/archderm.117.11.705
Abstract
The prevalence of antibodies to melanocytes was determined by an immunofluorescence complement fixation technique in 294 patients with vitiligo, other pigmentary disorders and unrelated dermatoses. Antimelanocyte antibodies were present in the sera of 5 (29%) of 17 patients with chronic mucocutaneous candidiasis. Only 2 of the 5 patients with antibodies had vitiligo. No antibodies to melanocytes were found in the sera of 31 patients with common vitiligo or of 38 patients with vitiligo associated with autoimmune diseases or melanoma. Nor were antibodies to melanocytes found in 129 patients with other diseases of pigment-producing cells or in a control group of 79 patients with nonpigmentary dermatoses. Thus, complement fixing antibodies to melanocytes are associated with chronic mucocutaneous candidiasis but are not involved in the pathogenesis of common vitiligo.This publication has 1 reference indexed in Scilit:
- Vitiligo in Graves' DiseaseAnnals of Internal Medicine, 1969