Plant Antimutagenic Agents, 5. Isolation and Structure of Two New Isoflavones, Fremontin and Fremontone from Psorothamnus fremontii
- 1 July 1989
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 52 (4) , 769-773
- https://doi.org/10.1021/np50064a017
Abstract
Two new isoflavones, fremontin [1] and fremontone [2], were isolated from roots of Psorothamnus fremontii (Fabaceae), a desert plant. Compound 1 has the structure 5''-(.alpha.,.alpha.-dimethylallyl)-5,7,2'',4''-tetrahydroxyisoflavone; compound 2 is similar but also contains the 3''-(.gamma.,.gamma.-dimethylallyl) substituent. The .alpha.,.alpha.-dimethylallyl substituent is rarely observed, and the combination of the .alpha.,.alpha.- and .gamma.,.gamma.-dimethylallyl substituents is unprecedented. Both 1 and 2 were nontoxic toward Salmonella typhimurium and were both highly active in the inhibition of mutagenicity of ethyl methanesulfonate (EMS) at all concentrations tested. Compound 2 was more active than 1 in the inhibition of mutagenicity of 2-aminoanthracene (2AN) and acetylaminofluorene (AAF) toward S. typhimurium.This publication has 2 references indexed in Scilit:
- Plant Antimutagenic Agents, 2. FlavonoidsJournal of Natural Products, 1988
- Plant Antimutagenic Agents, 1. General Bioassay and Isolation ProceduresJournal of Natural Products, 1988