Humoral immune stimulation and antiepithelial antibodies in yersinia infection

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Abstract
Results consistent with a general humoral immune stimulation were found when 127 sera from 89 patients with Yersinia enterocolitica infection were studied. Significantly increased gammaglobulin concentrations and elevated isohemagglutinin titers were seen in these sera as compared to sera from normal blood donors and patients with streptococcal infection. Antinuclear and anti–smooth muscle antibodies were demonstrated in both yersinia and streptococcal infection. The prevalence of non–organ specific antiepithelial antibodies reacting with gastrointestinal and thyroid epithelial cells was significantly increased in yersinia infection.