Effect of dipyridamole on vasodilator responses to ischemia, hypoxia, ATP, and AMP

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Abstract
The effect of intravenous administration of dipyridamole on the vasodilator responses to intraarterial AMP and ATP, to ischemia and to systemic hypoxia on blood vessels of the hindlimb of the anesthetized dog were evaluated using a preparation with free flow and a preparation perfused at constant flow. Dipyridamole produced decrease in systemic arterial blood pressure but did not affect limb vascular resistance. Following dipyridamole administration the responses to intra-arterial AMP and ATP were significantly enhanced, but the responses to circulatory arrest or to systemic hypoxia induced by breathing 8% were not significantly affected; also, the pressure-flow relationships of the vascular bed of the hindlimb were not altered by dipyridamole administration. Release of AMP or ATP does not contribute to the production of the vasodilator responses of limb blood vessels to ischemia up to 30 sec duration or to systemic hypoxia (average arterial blood oxygen tension 403 mm Hg).

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