Transient bradycardia during vespid venom immunotherapy

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Abstract
A woman developed generalized symptoms of hypersensitivity when she was stung requiring treatment with adrenalin, [epinephrine]. Intradermal venom skin tests showed immediate hypersensitivity to yellow hornet and white-faced hornet, fulfilling the criteria to receive appropriate venom immunotherapy. During the course of modified rush immunotherapy with yellow hornet and white-faced hornet venoms, she developed transient, but progressive bradycardia nesessitating interruption of the venom immunotherpay. Transient bradycardia recurred when venom immunotherapy was resumed but it was possible to reach a maintenance dose of 100 .mu.g protein for each venom. Bradycardia is induced in experimental animals by oriental hornet venom and other venoms, through a direct cholinergic action. A similar effect may occur in man in susceptible individuals during venom immunotherapy.

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