STUDIES ON ENHANCEMENT OF ANTI-TUMOR EFFECT .2. COMBINATION EFFECT OF RESERPINE WITH ANTI-TUMOR AGENTS IN L1210

  • 1 January 1980
    • journal article
    • research article
    • Vol. 71  (3) , 408-414
Abstract
The antileukemic combined effect of reserpine with 1-.gamma.-chloropropyl-2-chloromethylpiperidine hydrobromide (CAP-2) and other antitumor agents was studied on mouse leukemia L1210 in comparison with the effects of other Rauwolfia alkaloids and sympatholytic drugs. When reserpine was administered by a single i.p. injection (2.5 mg/kg) on day 1, the effect of subsequent administration of CAP-2, mitomycin-C or vinblastine was synergistically enhanced. In this combination with reserpine, the acute lethality of CAP-2 on the host animals was apparently decreased. Rescinnamine, a CNS depressant, slightly potentiated the antitumor effect of CAP-2. When reserpine-induced hypothermia was prevented by maintenance of the ambient temperature at 30.degree. C, the synergistic combined effect of reserpine was diminished. Chlorpromazine-induced hypothermia did not influence the antitumor effect of CAP-2. The antileukemic synergism depends partially on the interaction between reserpine and CAP-2 or other antitumor agents in relation to body temperature and/or action on the CNS in leukemic mice.