Activity of amoxycillin, alone, and in combination with aminoglycoside antibiotics against streptococci associated with bacterial endocarditis

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Abstract
Clinical isolates of Streptococcus viridans, Streptococcus bovis and enterococci (Streptococcus faecalis) were tested for sensitivity to amoxycillin, ampicillin and benzylpenicillin and to streptomycin, kanamycin, gentamicin, tobramycin, amikacin and dibekacin. Amoxycillin was more active than ampicillin and benzylpenicillin against enterococci and was as avtive as benzylpenicillin and more active than ampicillin against S. bovis an viridans streptococci. The strains of S. bovis and S. viridans were more sensitive to the penicillins than were the enterococci, and amoxycillin demonstrated greater bactericidal activity against the first two species than against the last. Combinations of amoxycillin and aminoglycosides generally produced greater bactericidal effects than did amoxycillin alne against all three species of streptococci unless the organism was resistant to the aminoglycoside. Kanamycin-resistant strains of S. faecalis showed an increased resistance to amikacin in tests of bactericidal activity.

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