Reduced natural killer T‐cells in B‐cell chronic lymphocytic leukaemia identified by three monoclonal antibodies: Leu‐11, A10, AB8.28

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Abstract
Summary. The proportion of E‐rosette positive T‐lymphocytes capable of reacting with three monoclonal antibodies (MoAbs)—Leu‐11, A10, AB8.28—‐ which appear to recognize specifically natural killer (NK) cells, was assessed in a series of untreated patients with B‐cell chronic lymphocytic leukaemia (B‐CLL). Irrespective of the clinical stage of the disease, the capacity of B‐CLL T‐lymphocytes to react with all three MoAbs was significantly reduced compared with that of normal circulating T‐cells (Leu‐11: 2·5%±1·9SD; A10: 2·3% 1·3; AB8.28: 7%±6·6 v Leu‐11: 13·5%±4·5; A10: 8·5%±4·6: AB8.28: 12% 5·5) Furthermore, a marked difference was demonstrated between the reactivity with the Leu‐11, A10, AB8.28 MoAbs and the proportion of Leu‐7 positive T‐cells, which in B‐CLL is significantly higher than in normal blood (23%±12·1 v 11·9%±5·9).These findings are in agreement with previous evidence of a discrepancy in B‐CLL between the phenotypic expression, assessed by Leu‐7 positivity, and the true functional activity of NK T‐cells, and suggest that the Leu‐11, A10 and AB8.28 MoAbs correlate well with the depressed NK function found in this disease.

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