Value of Thin-Layer Chromatography in Two Fatal Cases of Intoxication Due to Lidocaine and Mepivacaine

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Abstract
AN adverse reaction to local anesthetics has long been recognized as a calculated risk in the use of these drugs.1 If such a reaction occurs characteristic clinical signs and symptoms signal the patient's deteriorating condition, but proper therapy, promptly instituted, usually ameliorates this condition. Although occasional deaths due to local anesthetics have been reported2 no such reports have heretofore been published on lidocaine or mepivacaine. Two fatal cases resulting from the use of these agents are the subject of this paper.Chemically and physically these two drugs are so similar that a new technic for their separation, thin-layer chromatography, was . . .