Correlations of Hemoglobin A1c and Metabolic Status in Nondiabetic, Borderline Diabetic, and Diabetic Macaca Nigra

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Abstract
Glycosylated hemoglobin A1c (HbA1c) increases from 2.6% in nondiabetic Macaca nigra to 7.9% in diabetic monkeys. Monkeys without overt hyperglycemia but with impaired glucose clearance, impaired insulin secretion, and increased postprandial glucose have a significant increase in glycosylation to 3.5% HbA1c. Two different forms of hemoglobin are electrophoretically distinguishable in this species due to an amino acid change in the globin beta-chain. Colorimetrie analysis established that glycosylation of the different hemoglobin forms was related only to metabolic status. Percentages of glycosylated hemoglobins indicate the inability of monkeys with varying severity of metabolic abnormalities to adequately maintain glucose homeostasis.