Biological activities of tyrosine-containing somatostatin analogs on inhibition of secretion of thyrotropin and growth hormone.

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Abstract
The following 5 tyrosine-containing analogs of somatostatin (GIF) were synthesized by the solid-phase method: Tyr-GIF; [Tyr6]-GIF; [Tyr7]-GIF; [Tyr8]-GIF; [Tyr11]-GIF. These analogs except [Tyr8]-GIF possessed almost the same potency to inhibit thyrotropin release stimulated by thyrotropin-releasing hormone [in rats] as that of synthesized GIF in vivo. [Tyr8]-GIF had potencies less than 0.5% of GIF. They also had the activity to inhibit Nembutal-induced growth hormone rise. The structure-activity relationship and availability of these analogs for radioimmunoassay were discussed.

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