Ventricular Excitability During Hypothermia and Rewarming in the Dog.

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Abstract
When dogs under pentobarbital anesthesia are subjected to immersion hypothermia, alterations in ventricular excitability occur which depend chiefly upon concomitant blood pH changes. In all portions of the excitability cycle of the ventricle the threshold diminishes as body temperature is lowered to 25[degree] C when respiration is spontaneous (and blood pH therefore decreases), and reverses upon rewarming to normal body temperature. However, ventricular excitability does not change during hypothermia, provided the blood pH is maintained at a normal level by controlled artificial ventilation throughout the cooling process. Both the total "refractory" period and the ventricular conduction time are prolonged during cooling and return to normal during rewarming.

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