Identification of the major urinary metabolites of (+)-catechin and 3-O-methyl-(+)-catechin in man

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Abstract
Following oral administration of (+)-catechin and 3-O-methyl-(+)-catechin to human volunteers the major urinary metabolites were shown to be the glucuronides of 3′-O-methyl-(+)-catechin and 3,3′-O-dimethyl-(+)-catechin respectively. Isolations from urine and from synthetic products have been carried out by semi-preparative high performance liquid chromatography; definitive elucidations of structures have been carried out by gas chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy.