Isolated Lactase Deficiency
- 1 September 1967
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 120 (3) , 261-269
- https://doi.org/10.1001/archinte.1967.00300030003003
Abstract
Several studies concerning isolated lactase deficiency have appeared recently.1-9Agreement has not been reached, however, concerning the interpretation of human intestinal disaccharidase activity10and the lactose tolerance test.11,12Previous studies from our laboratory reported early experience with oral tolerance tests using different amounts of lactose13and described seven individuals with isolated lactase deficiency.14,15Through a cooperative study involving three medical centers, we have now accumulated data on 47 individuals with this defect. The current report compares the findings in these persons with those in a group of subjects with normal lactase activity and presents our concept of the significance of an isolated lactase deficiency based on these results. Material and Methods The studies were done on 170 individuals. There were 109 males, 61 females, 145 whites, 22 Negroes, and three American Indians. The patients ranged in age from 3 to 80 years with only threeThis publication has 18 references indexed in Scilit:
- Isolated Lactase Deficiency Producing Postgastrectomy Milk IntoleranceAnnals of Internal Medicine, 1966
- Lactosuria and Lactase Deficiency in Adult Celiac DiseaseGastroenterology, 1965
- Lactose Tolerance in Relation to Intestinal Lactase ActivityGastroenterology, 1965
- Secondary Disaccharidase Deficiency in Adult Celiac Disease (Nontropical Sprue) and Other Malabsorption StatesNew England Journal of Medicine, 1964
- Intestinal lactase deficiency and diarrhea in adultsDigestive Diseases and Sciences, 1964
- Method for assay of intestinal disaccharidasesAnalytical Biochemistry, 1964
- In Vitro Stabilization of Blood Glucose with WaterClinical Chemistry, 1963
- The prediabetic stateThe American Journal of Medicine, 1961
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951
- CRITERIA FOR AND INTERPRETATION OF NORMAL GLUCOSE TOLERANCE TESTSAnnals of Internal Medicine, 1950