MAMMARY-TUMOR VIRUS (MTV)-SPECIFIC IMMUNE-COMPLEX DEPOSITS IN RENAL GLOMERULI OF MTV-INFECTED TUMOR-FREE MICE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 35  (2) , 253-257
Abstract
Direct and indirect immunofluorescence tests revealed MTV-specific immune complex deposits in tumor-free female mice of the strains C3H/Bln, CBA/Bln, XVII/BlnfCBA/Bln and CBA/BlnfXVII/Bln. These deposits consisted of immunoglobulin, complement and MTV antigen(s). The immune complex deposition increased with age. Antibodies eluted from renal tissue homogenates reacted with MTV-A and -B particles in immunofluorescence tests performed on mouse mammary tumor slices. These results confirmed and completed the earlier finding of age-dependent spontaneously occurring antiMTV antibodies in naturally MTV-infected mice.

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