The Fate Of Gonococci In Polymorphonuclear Leucocytes

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Abstract
The fate of three freshly isolated strains of N. gonorrhoeae following phagocytosis by human or guinea-pig polymorphs was studied in vitro. Less than 1 per cent. of gonococci phagocytosed by the guinea-pig cells survived at 100 min., but some 20 per cent. of gonococci associated with the human polymorphs were not killed even after 3 hr. The persisting gonococci were destroyed when the polymorphs were exposed to penicillin and this indicates that the surviving bacteria lay outside the polymorph membrane.

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