Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation
Open Access
- 14 March 2011
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 25 (7) , 2234-2244
- https://doi.org/10.1096/fj.10-178673
Abstract
We report how rotational variations in transmembrane (TM) helix interactions participate in the activity states of the thrombopoietin receptor (TpoR), a type 1 cytokine receptor that controls the pr...Keywords
Funding Information
- Pfizer (N‐926702)
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