Type II collagen-induced arthritis in mice. III. Suppression of arthritis by using monoclonal and polyclonal anti-Ia antisera.
Open Access
- 1 April 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 134 (4) , 2366-2374
- https://doi.org/10.4049/jimmunol.134.4.2366
Abstract
Pretreatment of mice genetically susceptible to type II collagen-induced arthritis (CIA) with monoclonal or polyclonal antisera specific for I region gene products (Ia antigens) suppressed or delayed the onset of CIA, whereas pretreatment with anti-Ia to an irrelevant haplotype was without effect. The humoral response to type II collagen was transiently depressed 14 days after immunization but antibody levels did not differ significantly after 28 days. The peak delayed-type hypersensitivity to type II collagen was unaffected by anti-Ia treatment. Monoclonal antibody of one anti-Ia specificity enhanced both the antibody response and the arthritis incidence in one mouse strain.This publication has 2 references indexed in Scilit:
- Passive Transfer of Arthritis to Mice by Injection of Human Anti-Type II Collagen AntibodyMayo Clinic Proceedings, 1984
- Immunogenetic control of experimental type ii collagen‐induced arthritisArthritis & Rheumatism, 1981