Role of zinc in blockade of excitotoxic action of quinolinic acid by picolinic acid
- 1 March 1998
- journal article
- research article
- Published by Springer Nature in Amino Acids
- Vol. 14 (1-3) , 257-261
- https://doi.org/10.1007/bf01345272
Abstract
This study examined whether picolinic acid (PIC) inhibits quinolinic acid (QUIN) — induced excitotoxicity through zinc chelation. Injection of QUIN into the nucleus basalis magnocellularis significantly depleted cortical choline acetyltransferase activity 7 days post injection and PIC inhibited this response. Zinc augmented the QUIN- but not NMDA-induced response. When PIC was co-administered with zinc, PIC failed to attenuate the QUIN-induced response. The inhibition of QUIN — induced cholinergic toxicity by PIC may involve chelation of zinc.Keywords
This publication has 10 references indexed in Scilit:
- Differential action of NMDA antagonists on cholinergic neurotoxicity produced by N‐methyl‐D‐aspartate and quinolinic acidBritish Journal of Pharmacology, 1996
- The 1993 Upjohn Award Lecture. Quinolinic acid induced brain neurotransmitter deficits: modulation by endogenous excitotoxin antagonistsCanadian Journal of Physiology and Pharmacology, 1994
- Picolinic acid blocks the neurotoxic but not the neuroexcitant properties of quinolinic acid in the rat brain: Evidence from turning behaviour and tyrosine hydroxylase immunohistochemistryNeuroscience, 1994
- Modulation of inhibitory and excitatory amino acid receptor ion channels by zincProgress in Neurobiology, 1994
- Zinc potentiates agonist-lnduced currents at certain splice variants of the NMDA receptorNeuron, 1993
- Action of picolinic acid and structurally related pyridine carboxylic acids on quinolinic acid-induced cortical cholinergic damageBrain Research, 1992
- Quinolinic acid and other kynurenines in the central nervous systemNeuroscience, 1985
- II. Excitotoxic models for neurodegenerative disordersLife Sciences, 1984
- A rapid radiochemical method for the determination of choline acetyltransferaseJournal of Neurochemistry, 1975
- Stability Constants of Picolinic and Quinaldic Acid Chelates of Bivalent Metals.The Journal of Physical Chemistry, 1957