ACUTE LUNG INFLAMMATION INDUCED IN THE RABBIT BY LOCAL INSTILLATION OF 1-0-OCTADECYL-2-ACETYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE OR OF NATIVE PLATELET-ACTIVATING FACTOR

  • 1 January 1983
    • journal article
    • research article
    • Vol. 112  (1) , 78-88
Abstract
The intratracheal instillation into rabbits of 1-0-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (AGEPC) or native platelet-activating factor (PAF) induced a dose-dependent acute pulmonary inflammation characterized by accumulation of macrophages in the alveolar space, degenerative and necrotic changes of alveolar epithelium, and accumulation of polymorphonuclear leukocytes (PMN) and platelets in the alveolar capillary lumens with degenerative changes of endothelial cells. Infiltration of alveolar septa by inflammatory cells and, in a later stage, pulmonary fibrosis were also observed. Intrabronchial instillation of lysoglyceryl ether phosphorylcholine (lyso-GEPC) produced no inflammatory changes or only mild ones. In comparison with acute inflammation induced by intratracheal instillation of C5a [complement component 5a] des Arg, which is mainly characterized by the presence of neutrophils, red blood cells, and fibrin in the alveolar space, AGEPC and native PAF seem to induce a more severe accumulation of macrophages in the alveolar space and septa and of platelet and PMN in the lumens of alveolar capillaries. The results are compatible with the concept that during inflammatory reaction an intraalveolar release of PAF contributes to the development of pulmonary injury.

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