Modelling of serial carcinoembryonic antigen changes in colorectal cancer

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Abstract
Carl J, Bentzen S M, Nargaard-Pedersen B, Kronborg O. Modelling of serial carcinoembryonic antigen changes in colorectal cancer. Scand J Clin Lab Invest 1993; 53: 751-755. Carcinoembryonic antigen (CEA) is a tumour marker mainly used for detection of recurrent colorectal cancer. CEA series in 295 patients, who had a macroscopic radical resection of a primary colorectal cancer were studied. A kinetic model was fitted to CEA series of individual patients. Applying the kinetic model recurrences were identified with a sensitivity of 70-80% and specificity of 80-90%. Simulations were performed in order to find the optimal sampling strategy for CEA during follow-up. Simulations showed that CEA determinations at a few weeks interval between would be optimal for early detection of recurrences.