Thrombophilias and Adverse Outcomes of Pregnancy — What Should a Clinician Do?

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Abstract
Approximately 1 to 5 percent of pregnant women have serious complications of pregnancy, such as severe preeclampsia, abruptio placentae, intrauterine fetal death, or severe fetal growth retardation. The rates are even higher among older women, those with preexisting vascular disease (e.g., chronic hypertension, renal disease, or type 1 diabetes mellitus), those with multiple fetuses, and those who have a history of one or more of the complications during a previous pregnancy.13 The triad of severe preeclampsia, abruptio placentae, and fetal growth retardation is an important cause of fetal death, delivery before 34 weeks of gestation, and neonatal illness and . . .