Coxsackievirus B3-Positive Mononuclear Leukocytes in Peripheral Blood of Swiss and Athymic Mice during Infection

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Abstract
Coxsackievirus B3 viremia in infected 14 day old Swiss and young adult nude mice is predominantly a plasma viremia. Despite high titers of virus in plasma, separated suspensions of red blood cells and polymorphonuclear leukocytes contain no virus. Virus-positive mononuclear leukocytes in blood may be present on days 2-4 of infection. Virus-positive mononuclear leukocytes may persist after virus is no longer in the plasma. These studies do not definitively identify the mononuclear population in blood which is virus-positive.

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