Diagnostic significance of salivary levels ofβ2-microglobulin in Sjögren's syndrome

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Abstract
To evaluate the diagnostic significance of salivary β2m in Sjögren's syndrome we measured salivary β2m levels in 19 patients with primary sicca syndrome (PSS), 15 with secondary Sjögren's syndrome (SSS) and compared the results with 20 normal healthy persons. We showed that β2m is specifically excreted in the saliva, because in normal saliva the concentration of β2m was unrelated to IgA levels. Also in normals, there was no relationship between serum and saliva concentrations of β2m. The mean saliva levels of β2m were increased in PSS (1.13±0.58) and SSS (1.39±0.69) compared with the levels in normals (0.53±0.22). The determination of β2m in the saliva can therefore be used as a noninvasive measurement for the confirmation of the diagnosis Sjögren's syndrome.