Idiotype‐Specific, Major Histocompatibility Complex Restricted T Cells are of both Th1 and Th2 Type

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Abstract
The lymphokine secretion patterns of seven independent 91–101.γ2315/1‐Ed specific. CD4+ T‐cell clones have been investigated. Six of the clones are of the Thl type as they secrete IL2 and IFNγ, but not IL4. Some of these SIX Thi clones produce TNF α/β, and some produce minor amounts of IL5 and IL6. One clone is of the Th2 type as it produces 1L4, IL5. and large amounts of 1L6. but not IL2, IFNγ or TNF. The Thl, Th2 classification does not have any stringent relationship to immunization protocol, fine specificity and Vα/Vβ gene segment utilization. The immunoregulatory significance of our findings for Id/MHC‐dependent T B cell interaction is discussed.

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