Catalytic Asymmetric Intramolecular Aminopalladation: Improved Palladium(II) Catalysts

Abstract
Cobalt oxazoline palladacyclic (COP) complex 4 containing acetate as a bridging ligand is an excellent catalyst for asymmetric intramolecular aminopalladation to synthesize 4-vinyloxazolidin-2-ones in 91−98% ee. In contrast to previously reported Pd(II) catalysts, COP-OAc (4) promotes the asymmetric cyclization of (Z)-allylic N-tosylcarbamates without prior activation by silver salts.