Bcl‐6 gene hypermutations in diffuse large B‐cell lymphoma of primary gastric origin

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Abstract
The presence of the bcl‐6 gene hypermutation was studied in 40 Hong Kong Chinese patients with diffuse large B‐cell lymphoma. The primary sites of involvement were nodal in 18 cases and gastric in 22. Hypermutations at the E1.11 segment of bcl‐6 gene were detectable in 16/22 (73%) primary gastric and 4/18 (22%) primary nodal lymphoma (P < 0.01). Three of the 22 cases of primary gastric but none of the nodal lymphoma had mutations at E1.12. The proportion of hypermutated cases in the group with bcl‐6 gene rearrangement was similar to that of the germ‐line group (70% v 75%). High frequency of bcl‐6 gene hypermutations was found in diffuse large B‐cell lymphoma of the stomach and they were independent of rearrangement of the gene as detected by Southern analysis. Unlike gene rearrangement, hypermutations of the bcl‐6 gene did not appear to carry any prognostic significance clinically.

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