Awaking stem cells from dormancy: growing old and fighting cancer
Open Access
- 8 May 2009
- journal article
- research article
- Published by Springer Nature in EMBO Molecular Medicine
- Vol. 1 (2) , 88-91
- https://doi.org/10.1002/emmm.200900019
Abstract
It is generally accepted that a distinguishing property of stem cells (SCs), as compared to their more differentiated progenitors, is that of infrequent division, often referred to as ‘quiescence’. As regards hematopoietic stem cells (HSC), their resistance to antiproliferative drugs supports this notion. Maintenance of quiescence is thought to be critical for the preservation of HSCs9 function.Keywords
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