CYPROHEPTADINE TREATMENT OF NELSON′S SYNDROME: RESTORATION OF PLASMA ACTH CIRCADIAN PERIODICITY AND REVERSAL OF RESPONSE TO TRF1,2

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Abstract
Administration of cyproheptadine for four months to a patient with Nelson′s Syndrome was associated with evidence of skin lightening, decreased plasma ACTH concentrations, return of a normal circadian periodicity of plasma ACTH concentrations, and lack of responsiveness of plasma ACTH concentrations to TRF administration, in contrast to the response seen in the untreated state.