A STUDY OF HEMOGLOBIN METABOLISM IN PAROXYSMAL HEMOGLOBINURIA
Open Access
- 1 May 1922
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1908)
- Vol. 29 (5) , 669-683
- https://doi.org/10.1001/archinte.1922.00110050119007
Abstract
The close relationship of the coloring matter of the red blood corpuscles to the pigments of the bile is now generally accepted. Proofs for the existence of this relationship are numerous, and have been obtained by many investigators. Hematoidin, chemically isomeric with bilirubin, has long been known to occur in old extravasations of blood. Stadelmann,1working on dogs with biliary fistulas, showed that free hemoglobin in the plasma, produced by the artificial destruction of red cells, or by the injection of hemoglobin into the circulation, caused an increase in the quantity of bilirubin in the bile. Stadelmann and Gorodecki,2by injecting a solution of hemoglobin either subcutaneously or intraperitoneally, also caused in dogs a marked and prolonged rise in bile pigment in the fistula bile. The work of Brusch and Yoshimoto,3on dogs with biliary fistulas and ligated bile ducts, showed that intravenous injections of hematin caused increased amounts ofThis publication has 0 references indexed in Scilit: